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Invitrogen™ Norepinephrine Transporter Polyclonal Antibody
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Catalog No. PIPA584997
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PIPA584997 100 μL
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Catalog No. PIPA584997 Supplier Invitrogen™ Supplier No. PA584997
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLA Highest antigen sequence indentity to the following orthologs: Mouse - 85%, Rat - 32%.

Norepinephrine Transporter [NET, or noradrenaline transporter (NAT)] is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression. Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Norepinephrine Transporter
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SLC6A2
Gene Accession No. P23975
Gene Alias NaCl-dependent norepinephrine transporter; NAT1; NE transporter; NET; NE-T; NET1; neurotransmitter transporter; neurotransmitter transporter, noradrenal; NORADR; noradrenaline; noradrenaline transporter; norepinephrine transporter; Slc6a2; SLC6A5; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter), member 2; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; solute carrier family 6 member 2; solute carrier family 6 member 5; transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
Gene Symbols SLC6A2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SLC6A2. Recombinant protein control fragment (Product #RP-108281).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6530
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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