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NPC1 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 139261AP150UL

Encompass_Preferred

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Catalog No. 50-172-9097


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Description

Description

This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.

Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.
Specifications

Specifications

NPC1
Polyclonal
Unconjugated
NPC1
Niemann Pick C1 protein, Niemann Pick disease, type C1, NPC1
Rabbit
Antigen Affinity Chromatography
RUO
4864
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.32 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O15118
NPC1
NPC1 Fusion Protein Ag4946
150 μL
Primary
Human
Antibody
IgG
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