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NPC1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 139261AP150UL

Description
This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.
Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.Specifications
NPC1 | |
Polyclonal | |
Unconjugated | |
NPC1 | |
Niemann Pick C1 protein, Niemann Pick disease, type C1, NPC1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
4864 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
0.32 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
O15118 | |
NPC1 | |
NPC1 Fusion Protein Ag4946 | |
150 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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