Tocris™ NSC 23766

Selective inhibitor of Rac1-GEF interaction; antioncogenic

Manufacturer: Tocris™ 2161/50

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Catalog No. 21-615-0R

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For Research Use Only


    Product Type NSC 23766
    Inhibitors NSC 23766
    Purity >98
    Molecular Weight 530.97
    Quantity 50mg

    Selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50µM) without affecting Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotyes in prostate cancer cells.

    • Chemical Name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
    • Formula: C24H35N7.3HCl
    • CAS Number: 1177865-17-6
    • Solubility: Soluble to 100mM in water and to 100mM in DMSO
    • Purity: >99

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