Tocris NSC 23766
Selective inhibitor of Rac1-GEF interaction; antioncogenic
Manufacturer: Tocris 2161/50
DescriptionSelective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50µM) without affecting Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotyes in prostate cancer cells.
- Chemical Name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
- Formula: C24H35N7.3HCl
- CAS Number: 1177865-17-6
- Solubility: Soluble to 100mM in water and to 100mM in DMSO
- Purity: >99
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