Tocris™ NU 7441

Potent and selective DNA-PK inhibitor

Manufacturer: Tocris™ 3712/50

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Catalog No. 37-125-0R

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For Research Use Only


    Product Type NU 7441
    Inhibitors NU 7441
    Purity >99
    Molecular Weight 413.49
    Quantity 50mg

    Potent and selective DNA-PK inhibitor (IC50 = 14nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISP-Cas9-mediated homology-directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ).

    • Chemical Name: 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
    • Formula: C25H19NO3S
    • CAS Number: 503468-95-9
    • Solubility: Soluble to 5mM in DMSO with gentle warming
    • Purity: >99

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