Tocris NU 7441
Potent and selective DNA-PK inhibitor
Manufacturer: Tocris 3712/50
DescriptionPotent and selective DNA-PK inhibitor (IC50 = 14nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISP-Cas9-mediated homology-directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ).
- Chemical Name: 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
- Formula: C25H19NO3S
- CAS Number: 503468-95-9
- Solubility: Soluble to 5mM in DMSO with gentle warming
- Purity: >99
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