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  5. Tocris Bioscience™ NU 7441

Tocris Bioscience™ NU 7441
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Catalog No. p-5545938
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective DNA-PK inhibitor

NU 7441 is a potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ∽40%.

Specifications

Quantity 10 mg
Product Type NU 7441
Purity >99%
Molecular Weight (g/mol) 413.49
Inhibitors NU 7441

For Research Use Only

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