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Tocris Bioscience™ NU 7441

Potent and selective DNA-PK inhibitor

Supplier:  Tocris Bioscience™ 3712/10

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Catalog No. 37-121-0R


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Description

Description

NU 7441 is a potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ∽40%.
Specifications

Specifications

>99%
10 mg
413.49
KU 57788
NU 7441
NU 7441
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