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OCT2 Antibody (OCT2/2137) - Azide and BSA Free, Novus Biologicals™
SDP

Catalog No. NBP275735 Shop All R&D Systems Products
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NBP275735 100 μg
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Catalog No. NBP275735 Supplier Novus Biologicals Supplier No. NBP275735
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Description

Mouse Monoclonal Antibody

44471 Monoclonal specifically detects 44471 in Human samples. It is validated for Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.

Specifications

Antigen OCT2
Applications Western Blot, ELISA, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone OCT2/2137
Concentration 0.2 mg/ml
Conjugate Unconjugated
Dilution Western Blot 2 ug/ml, ELISA, Immunohistochemistry-Paraffin 1-2 ug/ml
Formulation 10 mM PBS with No Preservative
Gene Accession No. P09086
Gene Alias homeobox protein, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, OCT2Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, OTF2POU domain class 2, transcription factor 2, POU class 2 homeobox 2, POU domain, class 2, transcription factor 2
Gene Symbols POU2F2
Host Species Mouse
Immunogen Recombinant fragment of human OCT2 protein (around aa 112-297) (exact sequence is proprietary) (Uniprot: P09086)
Molecular Weight of Antigen 60 kDa
Purification Method Protein A or G purified
Quantity 100 μg
Research Discipline Cancer
Primary or Secondary Primary
Gene ID (Entrez) 5452.0
Test Specificity OCT2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. OCT2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of OCT2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of OCT2. Several studies of OCT2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for OCT2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.
Target Species Human
Content And Storage Store at 4°C.
Form Purified
Isotype IgG1 κ
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