OCT2 Antibody (OCT2/2137), DyLight 550, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP275735R

Catalog No. NB008704

Description

44471 Monoclonal specifically detects 44471 in Human samples. It is validated for Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: OCT2
• Classification: Monoclonal
• Conjugate: DyLight 550
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: POU2F2
• Immunogen: Recombinant fragment of human OCT2 protein (around aa 112-297) (exact sequence is proprietary) (Uniprot: P09086)
• Quantity: 0.1 mL
• Research Discipline: Cancer
• Test Specificity: OCT2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. OCT2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of OCT2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of OCT2. Several studies of OCT2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for OCT2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.
• Content And Storage: Store at 4°C in the dark.

• Applications: Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: Oct2/2137
• Dilution: Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: homeobox protein, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, OCT2Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, OTF2POU domain class 2, transcription factor 2, POU class 2 homeobox 2, POU domain, class 2, transcription factor 2
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG1 κ