OTUD7B Mouse anti-Human, Clone: 2C12D9, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 662761IG150UL

Catalog No. 50-173-6708

Description

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ′Lys-48′-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ′Lys-11′, ′Lys-48′ or ′Lys-63′- linked polyubiquitin chains. In vitro, has preference for ′Lys- 11′-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

Specifications

• Antigen: OTUD7B
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6GQQ9
• Gene Symbols: OTUD7B
• Immunogen: OTUD7B Fusion Protein Ag10513
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: 2C12D9
• Conjugate: Unconjugated
• Gene: OTUD7B
• Gene Alias: CEZANNE, OTU domain containing 7B, OTUD7B, ZA20D1, Zinc finger protein Cezanne
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 56957
• Content And Storage: -20°C
• Form: Liquid