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Tocris Bioscience™ Ozanimod

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Quantity:
10 mg
50 mg
Description
Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4. In vitro, Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells. In vivo, Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.
Specifications
Specifications
Chemical Name or Material | 5-[3-[(1 S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1 H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile |
CAS | 1306760-87-1 |
Quantity | 10 mg |
Target | Sphingosine-1-phosphate Receptor Agonists |
Molecular Formula | C23H24N4O3 |
Purity | 0.98 |
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