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p14ARF Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
$151.31 - $568.26
Specifications
| Antigen | p14ARF |
|---|---|
| Applications | Immunohistochemistry |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Form | Liquid |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-157-1660
|
Bethyl Laboratories, Inc
IHC00196T |
10 μL |
Each for $151.31
|
|
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50-157-1659
|
Bethyl Laboratories, Inc
IHC00196 |
100 μL |
Each for $568.26
|
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Description
The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan and White-tufted-ear marmoset
The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14ARF arrests the cell cycle in a p53-dependent manner. p14ARF binds to mdm2 and promotes the rapid degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1Beta-encoded N-terminal domain of p14ARF and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways.Specifications
| p14ARF | |
| Polyclonal | |
| Liquid | |
| RUO | |
| TBS with 0.1% BSA and 0.09% sodium azide | |
| ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, TP16, p14, p14ARF, p16, p16INK4, p16INK4a, p19, p19Arf | |
| CDKN2A | |
| IgG | |
| Antigen affinity chromatography | |
| Antibody |
| Immunohistochemistry | |
| Unconjugated | |
| Rabbit | |
| Human | |
| Q8N726 | |
| 1029 | |
| Between 125 and C-term | |
| Primary | |
| 4° C | |
| CDKN2A |
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