Invitrogen™ PAK2 Polyclonal Antibody

Catalog No.	Quantity
PIPA5143854	100 μg

Catalog No. PIPA5143854

Supplier: Invitrogen™ PA5143854

Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human HEK293 whole cell, rat thymus tissue, mouse thymus tissue. IHC: human appendiceal adenocarcinoma tissue, human lung cancer tissue, mouse skeletal muscle tissue, rat skeletal muscle tissue. ICC/IF: MCF-7 cell. Flow: U251 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

PAK2 (serine/threonine-protein kinase PAK2) is a serine/threonine kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, or proliferation. It acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformation change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.

Specifications

• Antigen: PAK2
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: Pak2
• Gene Accession No.: Q13177, Q64303, Q8CIN4
• Gene Alias: 5330420P17Rik; A130002K10Rik; AI836325; Alpha-PAK; Beta-PAK; C-t-PAK2; D16Ertd269e; gamma pak; gamma-PAK; mKIAA4182; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 2; p21 (RAC1) activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p27; p34; p58; p65-PAK; PAK alpha; PAK beta; PAK gamma; PAK1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK65; PAKgamma; S6/H4 kinase; serine/threonine-protein kinase PAK 2
• Gene Symbols: Pak2
• Host Species: Rabbit
• Immunogen: E.coli-derived human PAK2 recombinant protein (Position: M1-K288).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 224105, 29432, 5062
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG