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PALB2 Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7140735
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50-155-9876 20 μL
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Catalog No. 50-155-9876 Supplier Bethyl Laboratories, Inc Supplier No. A301246AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.

Specifications

Antigen PALB2
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene PALB2
Gene Accession No. Q86YC2
Gene Alias FANCN, Fanconi anemia, complementation group N, FLJ21816, PNCA3
Gene Symbols PALB2
Host Species Rabbit
Immunogen Between 200 and 250
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79728
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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