Parkin Recombinant Rabbit Monoclonal Antibody (21H24L9), HRP, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
70-278-5RHRP2	Invitrogen™ 702785RHRP20UG	20 μg
70-278-5RHRP	Invitrogen™ 702785RHRP	50 μg

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include: better specificity, lot-to-lot consistency, and broader immunoreactivity to diverse targets due to a larger rabbit immune repertoire. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

The precise function of Parkin gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Specifications

• Antigen: Parkin
• Concentration: 1.0 mg/mL
• Classification: Recombinant Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with proprietary stabilizer and proprietary preservative; pH 7.4
• Gene Alias: AAN12155.1; AR-JP; CG10523; CG10523-PB; CG10523-PC; Dmel\CG10523; Dmel_CG10523; Dpark; dParkin; D-parkin; dpk; E3 ubiquitin ligase; E3 ubiquitin-protein ligase parkin; LPRS2; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; park; park1; PARK2; Parkin; parkin 2; parkin F; Parkin isoform 1; parkin protein; parkin RBR E3 ubiquitin protein ligase; Parkin RBR E3 ubiquitin-protein ligase; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; parkinson protein 2 E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase (parkin); park-PB; park-PC; PDJ; PK; Prkn; SD01679
• Gene Symbols: PRKN
• Isotype: IgG
• Purification Method: Protein A
• Product Type: Antibody

• Clone: 21H24L9
• Applications: Western Blot
• Conjugate: HRP
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O60260, Q9JK66, Q9WVS6
• Gene ID (Entrez): 5071, 50873, 56816
• Immunogen: Protein corresponding to human Parkin (aa1-aa465).
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: PRKN