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PCL2 Mouse anti-Human, Clone: 3A9, Active Motif™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$135.30 - $534.00

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen PCL2
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3191 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61154
10 μg
Each for $135.30
Add to cart
 
50-199-3190 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
61153
100 μg
Each for $534.00
Add to cart
 
Description

Description

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter
Specifications

Specifications

Monoclonal
Primary
PCL2
Unconjugated
SDS
Product Certifications
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