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Invitrogen™ PD-1 Recombinant Human Monoclonal Antibody (HN94)
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Catalog No. PIMA543078
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200 μg
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PIMA543078 200 μg
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Catalog No. PIMA543078 Supplier Invitrogen™ Supplier No. MA543078
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Description

Human Recombinant Monoclonal Antibody

Specificity: Human PD1/PDCD1/CD279 KD of the antibody is <1.43E-10 M for PD1 (10377-H08H).

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of danger signals such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
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Specifications

Antigen PD-1
Applications Neutralization
Classification Recombinant Monoclonal
Clone HN94
Concentration 5.08 mg/mL
Conjugate Unconjugated
Formulation Arginine, histidine with 120mM NaCl, 0.02% Tween 80 and no preservative
Gene Pdcd1
Gene Accession No. Q15116
Gene Alias CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Gene Symbols Pdcd1
Host Species Human
Immunogen Recombinant Human PD1/PDCD1/CD279 Protein.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5133
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG4
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