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PD 198306, Tocris Bioscience™

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Quantity:
10 mg
This item is not returnable. View return policy
212631-61-3
C18H16F3IN2O2
476.238
UHAXDAKQGVISBZ-UHFFFAOYSA-N
unii-wq5121zgt3, benzamide, n-cyclopropylmethoxy-3,4,5-trifluoro-2-4-iodo-2-methylphenyl amino, n-cyclopropylmethoxy-3,4,5-trifluoro-2-4-iodo-2-methylphenyl amino-benzamide, n-cyclopropylmethoxy-3,4,5-trifluoro-2-4-iodo-2-methylphenylamino benzamide
9956637
N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-(4-iodo-2-methylanilino)benzamide
CC1=C(C=CC(=C1)I)NC2=C(C(=C(C=C2C(=O)NOCC3CC3)F)F)F
This item is not returnable. View return policy
212631-61-3
C18H16F3IN2O2
476.238
UHAXDAKQGVISBZ-UHFFFAOYSA-N
unii-wq5121zgt3, benzamide, n-cyclopropylmethoxy-3,4,5-trifluoro-2-4-iodo-2-methylphenyl amino, n-cyclopropylmethoxy-3,4,5-trifluoro-2-4-iodo-2-methylphenyl amino-benzamide, n-cyclopropylmethoxy-3,4,5-trifluoro-2-4-iodo-2-methylphenylamino benzamide
9956637
N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-(4-iodo-2-methylanilino)benzamide
CC1=C(C=CC(=C1)I)NC2=C(C(=C(C=C2C(=O)NOCC3CC3)F)F)F

Description

Selective inhibitor of MEK1/2

Potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC50 values are > 1, > 4, > 4 and > 10 μM for ERK, c-Src, cdks and PI 3-kinase γ respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration.
Quantity 10 mg
Formula Weight 476.23
Percent Purity >98%
Chemical Name or Material PD 198306

Safety and Handling

Recommended Storage : Store at +4°C

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