PD-L1/CD274 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 2B11D11, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 662481IG150UL

Catalog No. 50-100-3217

Description

PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.

Specifications

• Antigen: PD-L1/CD274
• Classification: Monoclonal
• Concentration: 1.55 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9EP73, Q9NZQ7
• Gene Symbols: CD274
• Immunogen: PD-L1/CD274 Fusion Protein Ag12443
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Porcine, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: 2B11D11
• Conjugate: Unconjugated
• Gene: CD274
• Gene Alias: B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 29126, 499342, 574058, 60533
• Content And Storage: -20°C
• Form: Liquid