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PD-L1 Recombinant Rabbit Monoclonal Antibody (BLR020E), Bethyl Laboratories

Catalog No. 501571293
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50-157-1293 100 μL
50-157-1294 10 μL
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Catalog No. 50-157-1293 Supplier Bethyl Laboratories, Inc Supplier No. A700020
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Description

Rabbit Recombit Monoclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform. PDL-1 antibody has no cross-reactivity to PDL-2.

Specifications

Antigen PD-L1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone BLR020E
Conjugate Unconjugated
Formulation BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene CD274
Gene Accession No. Q9NZQ7
Gene Alias B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1
Gene Symbols CD274
Host Species Rabbit
Immunogen Recombit protein representing the C-terminus of PD-L1
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29126
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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