PDE12 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 127531AP150UL

Catalog No. 50-172-8223

Description

PDE12 is an enzyme that cleaves 2′,5′-phosphodiester bond linking adenosines of the 5′-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3′,5′-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Specifications

• Antigen: PDE12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PDE12
• Gene Alias: 2 PDE, 2′ PDE, 2,5 phosphodiesterase 12, PDE12, phosphodiesterase 12
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 201626, 211948, 306231
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Concentration: 0.14 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q3TIU4, Q6AXQ5, Q6L8Q7
• Gene Symbols: Pde12
• Immunogen: PDE12 Fusion Protein Ag3217
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG