PDE12 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8223	Proteintech Group Inc 127531AP150UL	150 μL

Description

PDE12 is an enzyme that cleaves 2′,5′-phosphodiester bond linking adenosines of the 5′-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3′,5′-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Specifications

• Antigen: PDE12
• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q3TIU4, Q6AXQ5, Q6L8Q7
• Gene ID (Entrez): 201626, 211948, 306231
• Immunogen: PDE12 Fusion Protein Ag3217
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: PDE12

• Concentration: 0.14 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: 2 PDE, 2′ PDE, 2,5 phosphodiesterase 12, PDE12, phosphodiesterase 12
• Gene Symbols: Pde12
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody