PDK1 Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-156-1850	20 μL

Catalog No. 50-156-1850 Supplier Bethyl Laboratories, Inc Supplier No. A302130AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.

Specifications

• Antigen: PDK1
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: PDPK1
• Gene Accession No.: O15530, Q9Z2A0
• Gene Alias: 3-phosphoinositide dependent protein kinase-1, hPDK1; PDK1
• Gene Symbols: Pdpk1
• Host Species: Rabbit
• Immunogen: Between 506 and 556
• Purification Method: Antigen affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18607, 5170
• Target Species: Human, Mouse
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG