PDK1 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-1850	Bethyl Laboratories, Inc A302130AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt.

PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.

Specifications

• Antigen: PDK1
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: 3-phosphoinositide dependent protein kinase-1, hPDK1; PDK1
• Immunogen: Between 506 and 556
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: PDPK1

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: O15530, Q9Z2A0
• Gene ID (Entrez): 18607, 5170
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody