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Pepsinogen C/PGC/Progastricsin Antibody (L10CC10), Novus Biologicals™
SDP

Catalog No. NBP142322 Shop All R&D Systems Products
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NBP142322 0.05 mg
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Catalog No. NBP142322 Supplier Novus Biologicals Supplier No. NBP142322
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Description

Mouse Monoclonal Antibody

Pepsinogen C/PGC/Progastricsin Monoclonal specifically detects Pepsinogen C/PGC/Progastricsin in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Pepsinogen C/PGC/Progastricsin
Applications Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone L10CC10
Concentration 0.1 mg/mL
Conjugate Unconjugated
Dilution Western Blot 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500
Gene Alias EC 3.4.23, EC 3.4.23.3, FLJ99563, gastricsin, PEPC, pepsin C, Pepsinogen C, pepsinogen group II, PGII, preprogastricsin, progastricsin (pepsinogen C)
Gene Symbols PGA3
Host Species Mouse
Immunogen The antibody reacts with the Pepsinogen II antigen.
Purification Method Protein A or G purified
Quantity 0.05 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 643834
Test Specificity The antibody is specific to human pepsinogen II with no cross reactivity to human pepsinogen I. Pepsinogen II is a group of precursor molecules for pepsin. These proteins are secreted into the gastric lumen by the pyloric glands of the gastric antrum and also by the chief and neck cells of the gastric corpus (oxyntic mucosa). Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and pyloric in differentiation (so called pseudopyloric metaplasia). Monoclonal antibody to pepsinogen II is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Pepsinogen II purified from human tissue was used as an immunogen.
Target Species Human
Content And Storage Store at 4C. Do not freeze.
Form Purified
Isotype IgG1
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