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Tocris Bioscience™ PF 04449613, >98%
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Catalog No. 591510
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Quantity:
10 mg
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Catalog No. 59-151-0

Supplier: Tocris Bioscience™ 5915/10

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Description

Potent PDE9 inhibitor; brain penetrant

PF 04449613 is a potent PDE9 inhibitor (IC50 = 22 nM). Also exhibits a high affinity for cGMP (Km ∼170 nM). PF 04449613 reduces body fat in mice with diet-induced obesity, stimulating mitochondrial activity in brown and white fat, and improving cardiometabolic syndrome symptoms. Brain penetrant.

Chemical Identifiers

CAS 1236858-52-8
Molecular Formula C21H25N5O3

Specifications

Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 10mM in 1eq. HCl with gentle warming
Formula Weight 395.45
Purity >98%
Molecular Weight (g/mol) 395.463
Chemical Name or Material 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]

Safety and Handling

Recommended Storage Store at -20°C
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