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PF 06465469, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
1407966-77-1
C30H33N7O2
523.641
CGJVMKJGKFEHTL-HSZRJFAPSA-N
discontinued see a191400',r-3-1-1-acryloylpiperidin-3-yl-4-amino-1h-pyrazolo 3,4-d pyrimidin-3-yl-n-3-methyl-4-1-methylethyl benzamide,r-3-1-1-acryloylpiperidin-3-yl-4-amino-1h-pyrazolo 3,4-d pyrimidin-3-yl-n-4-isopropyl-5-methylphenyl benzamide
71450146
3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benzamide
CC1=C(C=CC(=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=C3C(=NC=N4)N)C5CCCN(C5)C(=O)C=C)C(C)C
This item is not returnable. View return policy
1407966-77-1
C30H33N7O2
523.641
CGJVMKJGKFEHTL-HSZRJFAPSA-N
discontinued see a191400',r-3-1-1-acryloylpiperidin-3-yl-4-amino-1h-pyrazolo 3,4-d pyrimidin-3-yl-n-3-methyl-4-1-methylethyl benzamide,r-3-1-1-acryloylpiperidin-3-yl-4-amino-1h-pyrazolo 3,4-d pyrimidin-3-yl-n-4-isopropyl-5-methylphenyl benzamide
71450146
3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benzamide
CC1=C(C=CC(=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=C3C(=NC=N4)N)C5CCCN(C5)C(=O)C=C)C(C)C

Potent ITK inhibitor; also inhibits BTK

Potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50 = 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50 = 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50 values are 31 and 48 nM respectively).
Quantity 10mg
Formula Weight 523.63
Percent Purity >95%
Chemical Name or Material PF 06465469

Recommended Storage : Store at +4°C