PHIP Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 209331AP
DescriptionPHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing beta cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|ndrp, PH interacting protein, PHIP, WDR11|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|PHIP Fusion Protein Ag14968|
|Antigen Affinity Chromatography|
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