Invitrogen™ Phospho-4EBP1 (Thr37, Thr46) Recombinant Rabbit Monoclonal Antibody (4EB1T37T46-A5)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA527999	Invitrogen™ MA527999	200 μL
PIMA536935	Invitrogen™ MA536935	20 μL

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Specifications

• Antigen: Phospho-4EBP1 (Thr37, Thr46)
• Concentration: 0.5 mg/mL
• Applications: Flow Cytometry, Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q13541, Q60876, Q62622
• Gene ID (Entrez): 116636, 13685, 1978
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Thr37/46 of human phospho 4E-BP1.
• Product Type: Antibody

• Clone: 4EB1T37T46-A5
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG κ
• Target Species: Human, Mouse, Rat
• Gene: EIF4EBP1
• Gene Alias: 4EBP1; 4E-BP1; AA959816; BP-1; eIF4E-binding protein 1; EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; MGC431; MGC4316; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
• Gene Symbols: EIF4EBP1
• Primary or Secondary: Primary
• Purification Method: Protein A/G