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Invitrogen™ Phospho-AMPK alpha-2 (Thr172) Recombinant Rabbit Monoclonal Antibody (4F4)
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Catalog No. PIMA533216
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PIMA533216 100 μL
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Catalog No. PIMA533216 Supplier Invitrogen™ Supplier No. MA533216
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Description

Rabbit Recombinant Monoclonal Antibody

Phospho-AMPK alpha-2 (Thr172) Recombinant Monoclonal Antibody for Western Blot, ICC/IF, ELISA

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-AMPK alpha-2 (Thr172)
Applications ELISA, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 4F4
Concentration 3 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PRKAA2
Gene Accession No. P54646, Q8BRK8
Gene Alias 2310008I11Rik; 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; A830082D05; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP-activated protein kinase; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMP-activated protein kinase alpha-2 variant B; AMPK; AMPK alpha 2; AMPK alpha-2 chain; AMPK subunit alpha-2; AMPK2; AMPKa2; AMPKalpha2; AMPK-alpha-2 chain; EC 2.7.11.1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; PRKAA; Prkaa2; protein kinase AMP-activated catalytic subunit alpha 2; protein kinase, AMP-activated, alpha 2 catalytic subunit
Gene Symbols PRKAA2
Host Species Rabbit
Immunogen A synthesized peptide derived from human Phospho-PRKAA2 (Thr172).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108079, 5563
Target Species Human, Mouse
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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