Invitrogen™ Phospho-BLNK (Tyr84) Recombinant Rabbit Monoclonal Antibody (BLNKY84-H4)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA528004	Invitrogen™ MA528004	200 μL
PIMA537084	Invitrogen™ MA537084	20 μL

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

B cell linker protein (Blnk) is a protein encoded by the Blnk gene located on chromosome 10 in humans. It is also known as SLP 65 (Src homology 2 domain-containing leukocyte protein of 65 kDa). It derives its name from being an adaptor protein in the B cell receptor signaling cascade with several supporting studies showing improper development of B cells in the absence of Blnk. Blnk undergoes tyrosine phosphorylation by Syk, a B cell receptor activated kinase, which provides a platform for interaction of signaling intermediaries such as the Vav GEF and Grb2.

Specifications

• Antigen: Phospho-BLNK (Tyr84)
• Concentration: 0.5 mg/mL
• Applications: Flow Cytometry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8WV28
• Gene ID (Entrez): 29760
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr84 of human phospho BLNK.
• Product Type: Antibody

• Clone: BLNKY84-H4
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG κ
• Target Species: Human
• Gene: BLNK
• Gene Alias: AGM4; B cell adaptor containing SH2 domain; B cell linker; B cell linker protein; BASH; bca; B-cell activation; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker; B-cell linker protein; Blnk; BLNK-S; Cytoplasmic adapter protein; LY57; Ly-57; lymphocyte antigen 57; Lyw-57; MGC111051; SLP65; Slp-65; Src homology [SH2] domain-containing leukocyte protein of 65 kD; Src homology 2 domain-containing leukocyte protein of 65 kDa
• Gene Symbols: BLNK
• Primary or Secondary: Primary
• Purification Method: Protein A/G