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  6. Invitrogen™ Phospho-c-Met (Tyr1234, Tyr1235) Recombinant Rabbit Monoclonal Antibody (MetY12341235-6F11), APC

Invitrogen™ Phospho-c-Met (Tyr1234, Tyr1235) Recombinant Rabbit Monoclonal Antibody (MetY12341235-6F11), APC

Catalog No. p-200122604
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PIMA528021 100 Tests
PIMA537037 10 Tests
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-c-Met (Tyr1234, Tyr1235)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone MetY12341235-6F11
Conjugate APC
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene MET
Gene Accession No. P08581, P16056
Gene Alias AI838057; AUTS9; bHLHe59; CG1705; CG1705-PA; CG1705-PB; cmet; c-met; c-met proto-oncogene; c-Met receptor tyrosine kinase; c-Met/HGF receptor; D249; DFNB97; Dmel\CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; HGFR; HGF-SF receptor; juvenile hormone resistance; met; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; Met; protein tyrosin kinase; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; scatter factor receptor; SF receptor; soluble c met; tyrosine-protein kinase Met
Gene Symbols MET
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr1234/Tyr1235 of human phospho Met.
Purification Method Protein A/G
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17295, 4233
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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