Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Phospho-gamma-H2AX (Ser139) Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

$151.31 - $607.53

Specifications

Antigen Phospho-gamma-H2AX (Ser139)
Applications Immunocytochemistry, Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Form Liquid
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-157-1410
Encompass_Preferred
View Documents
Bethyl Laboratories, Inc
IHC00059T
10 μL
Each for $151.31
Only null left
Add to Cart
 
50-157-1409
Encompass_Preferred
View Documents
Bethyl Laboratories, Inc
IHC00059
100 μL
Each for $607.53
Only null left
Add to Cart
 
Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Rabbit, Guinea pig_10141, Pig, Monkey, Gorilla, Little brown bat, hirteen-lin

Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle. In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX. The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs. The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner. Structurally, H2A.x contains 143 amino acid residues. Histone H2A.X is considered a basal histone, being synthesized in G1 as well as in S-phase, and its mRNA contains polyA addition motifs and a polyA tail along with the conserved stem-loop and U7 binding sequences involved in the processing and stability of replication type histone mRNAs. There are two forms of Histone H2A.X mRNA, one about 1600 bases long and contains polyA; the other about 575 bases long, lacking polyA. The short form behaves as a replication type histone mRNA, while the longer behaves as a basal type histone mRNA. Histone H2A.X maps to the 11q23.2-q23.3 region of the human chromosome. Histone H2A.x contributes to histone-formation and therefore the structure of DNA. Histone H2A variant H2A.x specifically regulates the interaction of MDC1 (mediator of DNA damage checkpoint protein 1), a DNA repair protein to the sites of DNA damage.
Specifications

Specifications

Phospho-gamma-H2AX (Ser139)
Polyclonal
Liquid
RUO
TBS with 0.1% BSA and 0.09% sodium azide
H2A/X, H2AX, H2AX histone, histone H2AX
Surrounding serine 139
Primary
4° C
H2AFX
Immunocytochemistry, Immunohistochemistry
Unconjugated
Rabbit
Human, Mouse
P16104, P27661
15270, 3014
IgG
Antigen affinity chromatography
Antibody
Videos
SDS
Documents

Documents

Product Certifications
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.