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Phospho-GATA3 (Ser308) Polyclonal Antibody, Invitrogen™

Catalog No. PIPA538492
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100 μg
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Catalog No. Quantity
PIPA538492 100 μg
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Catalog No. PIPA538492 Supplier Thermo Scientific Supplier No. PA538492

Description

Rabbit Polyclonal Antibody

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-GATA3 (Ser308)
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GATA3
Gene Accession No. P23771, P23772
Gene Alias GATA-binding factor 3, GATA3, 2625, GATA3, 131320, P23771, HDR, MGC2346, MGC5199, MGC5445
Gene Symbols GATA3
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human GATA3 around the phosphorylation site of Ser308 (R-L-SP-A-A)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14462, 2625
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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