Invitrogen™ Phospho-PRAS40 (Thr246) Recombinant Rabbit Monoclonal Antibody (3A1F3)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
MA558237	Invitrogen™ MA558237	20 μL
MA558238	Invitrogen™ MA558238	100 μL

Description

Immunogen sequence: LNT(p)SD.

The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.

Specifications

• Antigen: Phospho-PRAS40 (Thr246)
• Concentration: 4.5 mg/mL
• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q96B36, Q9D1F4
• Gene ID (Entrez): 67605, 84335
• Immunogen: A synthetic phosphorylated peptide around T246 of human AKT1S1/PRAS40 (NP_001265088.1).
• Product Type: Antibody

• Clone: 3A1F3
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human, Mouse
• Gene: AKT1S1
• Gene Alias: 1110012J22Rik; 40 kDa proline-rich AKT substrate; AI227026; AKT1 substrate 1; AKT1 substrate 1 (proline rich); AKT1 substrate 1 (proline-rich); akt1s1; Lobe; Lobel; OTTHUMP00000196756; OTTHUMP00000196760; PKB/Akt substrate 40; Pras; PRAS40; Proline-rich AKT substrate; proline-rich AKT1 substrate 1
• Gene Symbols: AKT1S1
• Primary or Secondary: Primary
• Purification Method: Protein A