Phospho-Sp1 (Ser101) Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Supplier:  Active Motif 39757

Catalog No. 50-199-2830

Description

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

Specifications

• Antigen: Phospho-Sp1 (Ser101)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SP1
• Gene Alias: 1110003E12Rik; AA450830; AI845540; HGNC:11205; Sp1; Sp1 transcription factor; Sp1-1; Specificity protein 1; trans-acting transcription factor 1; Transcription factor Sp1; TSFP1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6667
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Dot Blot, Western Blot
• Concentration: Lot-Specific
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Accession No.: P08047
• Gene Symbols: SP1
• Immunogen: This Sp1 phospho Ser101 antibody was raised against a peptide containing phospho-serine 101 of human Sp1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG