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Invitrogen™ Phospho-SPHK1 (Ser225) Polyclonal Antibody
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Catalog No. PIPA5143772
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100 μL
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PIPA5143772 100 μL
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Catalog No. PIPA5143772 Supplier Invitrogen™ Supplier No. PA5143772
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Description

Rabbit Polyclonal Antibody

This antibody was cross-adsorbed to non-specific phosphoserine and unphosphorylated SK1 (Ser-225) peptide before affinity purification using phospho-SK1 (Ser-225) peptide. The purified antibody detects a 47 kDa* full-length recombinant human SK1 protein phosphorylated with ERK2.

SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
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Specifications

Antigen Phospho-SPHK1 (Ser225)
Applications Western Blot
Classification Polyclonal
Concentration 0.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 1 mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene SPHK1
Gene Accession No. Q9NYA1
Gene Alias 1110006G24Rik; Acetyltransferase SPHK1; RP23-193A16.4; SK 1; Sk1; SKase; Sphingosine kinase 1; SPHK; SPHK1; SPK; SPK 1; Spk1
Gene Symbols SPHK1
Host Species Rabbit
Immunogen Phospho-SK1 (Ser-225) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding serine 225 in human SK1. This sequence has 4 amino acid differences from mouse and 5 from rat SK1, and is not homologous to sequences in SK2. The conserved site in rat and mouse SK1 is at serine 224.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8877
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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