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  6. Invitrogen™ Phospho-Stat1 (Ser727) Recombinant Rabbit Monoclonal Antibody (Stat1S727-C6), PE

Invitrogen™ Phospho-Stat1 (Ser727) Recombinant Rabbit Monoclonal Antibody (Stat1S727-C6), PE

Catalog No. p-200116012
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PIMA528058 100 Tests
PIMA537073 10 Tests
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Catalog No. PIMA528058 Supplier Invitrogen™ Supplier No. MA528058
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Stat1 (Ser727)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone Stat1S727-C6
Conjugate PE
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene STAT1
Gene Accession No. P42224
Gene Alias 2010005J02Rik; AA408197; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT1; STAT-1; stat1 alpha; STAT91; transcription factor ISGF-3; transcription factor ISGF-3 components p91/p84
Gene Symbols STAT1
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Ser727 of human phospho Stat1.
Purification Method Protein A/G
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6772
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG κ
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