Invitrogen™ Phospho-STAT5 alpha/beta (Ser726, Ser731) Polyclonal Antibody

Catalog No.	Quantity
PIPA536767	100 μL

Catalog No. PIPA536767 Supplier Invitrogen™ Supplier No. PA536767

Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 90 kDa. Purity is >95% by SDS-PAGE.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Specifications

• Antigen: Phospho-STAT5 alpha/beta (Ser726, Ser731)
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene: STAT5A
• Gene Accession No.: P42229, P42230, P42232, P51692, P52632, Q62771
• Gene Alias: AA959963; Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; mammary gland factor; transcription factor; MGF; Mpf; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5a; Signal transducer and activator of transcription 5B; STA5B; STAT; STAT5; Stat5a; Stat5b; transcription factor STAT5B
• Gene Symbols: STAT5A, STAT5B
• Host Species: Rabbit
• Immunogen: Synthetic phosphopeptide derived from human Stat5a around the phosphorylation site of Serine 726.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20850, 20851, 24918, 25126, 6776, 6777
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG