Invitrogen™ Pi16 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547675

Catalog No. PIPA547675

Description

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human PI16 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The PI16 gene encodes the protein peptidase inhibitor 16, which is a member of the protease inhibitor family and plays roles in modulating protease activity within tissues. PI16 is primarily expressed in the prostate but is also found in other tissues, where it contributes to extracellular matrix organization and integrity by inhibiting serine proteases. By regulating protease activity, PI16 helps maintain tissue homeostasis and influences processes such as cell proliferation, differentiation, and migration. This protein's function is significant in preventing excessive proteolytic activity that could lead to tissue damage or contribute to pathological conditions like inflammation and cancer. Specifically, PI16's role in the prostate gland has been associated with modulating growth and repair mechanisms, providing potential implications in prostate cancer progression where protease activity is often dysregulated. Current research focuses on understanding PI16's interactions and regulatory mechanisms to explore its therapeutic potential in diseases characterized by abnormal protease activities.

Specifications

• Antigen: Pi16
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PI16
• Gene Alias: 1200009H11Rik; CD364; Cripi; CRISP9; CRISP-9; Cysteine-rich protease inhibitor; cysteine-rich secretory protein 9; microseminoprotein, beta-binding protein; MSMBBP; peptidase inhibitor 16; Pi16; PI-16; protease inhibitor 16; PSEC0164; PSP94-binding protein; PSPBP; UNQ289/PRO328
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 74116
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9ET66
• Gene Symbols: PI16
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Peptidase Inhibitor 16/PI16 Leu21-Glu455.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG