PP2A alpha Monoclonal Antibody (3B6), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA549213

Catalog No. PIMA549213

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Human PP2A-alpha shares 100% amino acid (aa) sequence identity with both mouse and rat PP2A-alpha.

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. The PP2A family comprises subfamily members PP2A alpha and PP2A beta. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.

Specifications

• Antigen: PP2A alpha
• Classification: Monoclonal
• Concentration: 500 μg/mL
• Formulation: PBS with 4MG trehalose and 0.01MG sodium azide
• Gene Accession No.: P63330, P63331, P67775
• Gene Symbols: PPP2CA
• Immunogen: E.coli-derived human PP2A-alpha recombinant protein (Position: M1-L309).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Non-human Primate, Rat
• Form: Lyophilized

• Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: 3B6
• Conjugate: Unconjugated
• Gene: PPP2CA
• Gene Alias: B55-GAMMA; hypothetical protein; IMYPNO; IMYPNO1; Methyl-PPP2CA; MGC33570; PP2A; PP2A alpha; PP2A C terminal; PP2A L9; PP2A Leucine 9; Pp2a1; PP2A-alpha; PP2Ac; PP2CA; PP2Calpha; Ppp2ca; PR52; PR55G; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2 catalytic subunit alpha; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2,catalytic subunit alpha isozyme; protein phosphatase 2A alpha subunit; protein phosphatase 2A catalytic subunit alpha isoform; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase type 2A catalytic subunit; protein phosphatase-2A; protein phosphatase-2A-alpha; R75353; replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; unnamed protein product
• Host Species: Mouse
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19052, 24672, 5515
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Isotype: IgG2a