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Tocris Bioscience™ PPADS tetrasodium salt

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Quantity:
10 mg
50 mg
Description
PPADS tetrasodium salt is a non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ∼ 0.9 mM), and recombinant P2Y4 (IC50 ∼ 15 mM) receptors. PPADS tetrasodium salt delays onset of calcium responses to mild hypoosmotic stress in cortical slices. PPADS tetrasodium salt blocks P2X7 and reduces clinical and histological graft-versus-host disease development in a humanised mouse model.
2'5'-isomer also available.
Specifications
Specifications
Quantity | 10 mg |
Formula Weight | 599.3 |
Purity | >98% |
Molecular Weight (g/mol) | 599.296 |
Chemical Name or Material | PPADS tetrasodium salt |
Safety and Handling
Recommended Storage | Desiccate at -20°C |
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