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  5. Tocris Bioscience™ PPADS tetrasodium salt

Tocris Bioscience™ PPADS tetrasodium salt
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Catalog No. 062550
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50 mg
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Catalog No. Quantity
06-255-0 50 mg
06-251-0 10 mg
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Catalog No. 06-255-0 Supplier Tocris Bioscience™ Supplier No. 0625/50
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Description

Non-selective P2 antagonist

PPADS tetrasodium salt is a non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ∼ 0.9 mM), and recombinant P2Y4 (IC50 ∼ 15 mM) receptors. PPADS tetrasodium salt delays onset of calcium responses to mild hypoosmotic stress in cortical slices. PPADS tetrasodium salt blocks P2X7 and reduces clinical and histological graft-versus-host disease development in a humanised mouse model.

2'5'-isomer also available.

Chemical Identifiers

CAS 192575-19-2
Molecular Formula C14H10N3Na4O12PS2

Specifications

Quantity 50 mg
Formula Weight 599.3
Purity >98%
Molecular Weight (g/mol) 599.296
Chemical Name or Material PPADS tetrasodium salt

Safety and Handling

Recommended Storage Desiccate at -20°C
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