PPP6C Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 158521AP150UL

Catalog No. 50-173-0529

Description

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5′ to 3′ exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5′ and 3′ overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5′ and 3′ overhang processing in nonhomologous DNA end joining.

Specifications

• Antigen: PPP6C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PPP6C
• Gene Alias: PP6C, PPP6, PPP6C
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171121, 5537, 67857
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O00743, Q64620, Q9CQR6
• Gene Symbols: Ppp6c
• Immunogen: PPP6C Fusion Protein Ag8670
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG