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PPP6C Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 158521AP

Catalog No. 50-173-0529


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Description

Description

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5 ft. to 3 ft. exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5 ft. and 3 ft. overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5 ft. and 3 ft. overhang processing in nonhomologous DNA end joining.
Specifications

Specifications

PPP6C
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O00743, Q64620, Q9CQR6
PP6C, PPP6, PPP6C
Rabbit
IgG
150 μL
-20°C
Primary
171121, 5537, 67857
Immunoprecipitation, Western Blot
Unconjugated
PPP6C
Liquid
Ppp6c
PPP6C Fusion Protein Ag8670
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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