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PRKAR1A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

$518.60

Specifications

Antigen PRKAR1A
Concentration 0.62 mg/mL
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-173-2845
SDP
Encompass_Preferred
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Proteintech Group Inc
203581AP150UL
150 μL
Each of 1 for $518.60
Only null left
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Description

Description

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme, resulting in release of active catalytic subunits. Four different PKA regulatory subunits have been identified, designated Ia, Ib, IIa and IIb. The PKA Ia reg protein is a tissue-specific extinguisher that downregulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional null mutations in the gene that codes for PKA Ia reg cause Carney complex (CNC). CNC is an autosomal domit multiple neoplasia syndrome. CNC is associated with a variety of characterized symptoms such as cardiac and other myxomas, spotty skin pigmentation, endocrine tumors and psammomatous melanotic schwannomas.
Specifications

Specifications

PRKAR1A
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Rabbit
Human, Mouse, Rat
P09456, P10644, Q9DBC7
19084, 25725, 5573
PRKAR1A Fusion Protein Ag14216
Primary
-20°C
PRKAR1A
0.62 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, PRKAR1A, Tissue specific extinguisher 1, TSE1
Prkar1a
IgG
Antigen Affinity Chromatography
Antibody
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SDS
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