Tocris™ PRT 4165

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

Manufacturer: Tocris™ 5047/10

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Catalog No. 504710R

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For Research Use Only


    Product Type PRT 4165
    Inhibitors PRT 4165
    Purity >99
    Molecular Weight 235.24
    Quantity 10mg

    Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50 = 3.9µM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). Also shown to inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo.

    • Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione
    • Formula: C15H9NO2
    • CAS Number: 31083-55-3
    • Solubility: Soluble to 100mM in DMSO and to 5mM in 1eq. HCl with gentle warming
    • Purity: >99

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