Tocris PRT 4165
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
Manufacturer: Tocris 5047/10
DescriptionInhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50 = 3.9µM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). Also shown to inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo.
- Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione
- Formula: C15H9NO2
- CAS Number: 31083-55-3
- Solubility: Soluble to 100mM in DMSO and to 5mM in 1eq. HCl with gentle warming
- Purity: >99
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