Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Azoles
  7. Imidazoles
  8. PSB 10 hydrochloride, Tocris Bioscience™

PSB 10 hydrochloride, Tocris Bioscience™

Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
591771-91-4
C16H15Cl4N5O
435.13
JUPMOTHIKGWECW-DDWIOCJRSA-N
psb 10 hydrochloride, 8-ethyl-1,4,7,8-tetrahydro-4-methyl-2-2,3,5-trichlorophenyl-5h-imidazo 2,1-i purin-5-one monohydrochloride
90488733
(8R)-8-ethyl-4-methyl-2-(2,3,5-trichlorophenyl)-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one;hydrochloride
CCC1CN2C(=N1)C3=C(N=C(N3)C4=CC(=CC(=C4Cl)Cl)Cl)N(C2=O)C.Cl
This item is not returnable. View return policy
591771-91-4
C16H15Cl4N5O
435.13
JUPMOTHIKGWECW-DDWIOCJRSA-N
psb 10 hydrochloride, 8-ethyl-1,4,7,8-tetrahydro-4-methyl-2-2,3,5-trichlorophenyl-5h-imidazo 2,1-i purin-5-one monohydrochloride
90488733
(8R)-8-ethyl-4-methyl-2-(2,3,5-trichlorophenyl)-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one;hydrochloride
CCC1CN2C(=N1)C3=C(N=C(N3)C4=CC(=CC(=C4Cl)Cl)Cl)N(C2=O)C.Cl

Description

Potent, highly selective hA3 receptor antagonist/inverse agonist

Potent and highly selective antagonist for the human adenosine A3 receptor, with low affinity for the rat A3 receptor (Ki values are 0.44 and > 17000 nM respectively). Displays > 3800-fold selectivity over human A1, A2A and A2B receptors (Ki values are 4.1, 3.3 and 30 μM respectively) and > 1800-fold selectivity over rat A1 and A2A receptors. Acts as an inverse agonist in the [35S]GTPγS binding assay in hA3-CHO cells (IC50 = 4 nM). Produces thermal hyperalgesia in mice in vivo.
Quantity 50 mg
Formula Weight 435.14
Percent Purity >98%
Chemical Name or Material PSB 10 hydrochloride

Safety and Handling

Recommended Storage : Desiccate at +4°C