Invitrogen™ PSMB6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIPA5119367	Invitrogen™ PA5119367	200 μL
PIPA5121890	Invitrogen™ PA5121890	20 μL

Description

PSMB6 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. This complex, consisting of alpha, beta, and gamma subunits, enhances the activity of the 20S proteolytic core. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelmane's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).

Specifications

• Antigen: PSMB6
• Content And Storage: -20°C
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: PSMB6
• Gene Alias: DELTA; Lmp19; LMPY; low molecular mass protein 19; Macropain delta chain; Mpnd; multicatalytic endopeptidase complex delta chain; proteasome (prosome, macropain) subunit, beta type 6; proteasome (prosome, macropain) subunit, beta type, 6; proteasome 20S subunit beta 6; proteasome beta 6 subunit; proteasome catalytic subunit 1; proteasome chain 5; Proteasome delta chain; proteasome subunit beta 6; proteasome subunit beta type-6; proteasome subunit delta; proteasome subunit Y; Psmb6; Psmb6l; PSY large multifunctional protease Y; RP23-122P1.4; subunit 2; Y
• Gene Symbols: PSMB6
• Primary or Secondary: Primary
• Purification Method: Antigen Affinity Chromatography

• Concentration: 500 μg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: P28072
• Gene ID (Entrez): 5694
• Immunogen: Recombinant protein Proteasome Subunit Beta Type 6. The antigen corresponds to amino acid range 2-239 of the target protein.
• Product Type: Antibody