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Tocris Bioscience™ PX 12
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Catalog No. 295410
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Catalog No. Quantity
29-541-0 10 mg
29-545-0 50 mg
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Catalog No. 29-541-0 Supplier Tocris Bioscience™ Supplier No. 2954/10
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Description

Thioredoxin-1 inhibitor

Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.

Chemical Identifiers

CAS 141400-58-0
Molecular Formula C7H12N2S2

Specifications

Quantity 10 mg
Formula Weight 188.31
Purity >99%
Molecular Weight (g/mol) 188.31
Chemical Name or Material PX 12

Safety and Handling

Recommended Storage Store at +4°C
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