Tocris R 7050
Inhibitor of TNF-alpha receptor 1 signaling
Manufacturer: Tocris 5432/10
DescriptionInhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.
- Chemical Name: 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
- Formula: C16H8ClF3N4S
- CAS Number: 303997-35-5
- Solubility: Soluble to 20mM in DMSO
- Purity: >98
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